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Updated: Sep 04, 2026
Q & A: 200 Questions and Answers
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| Section | Objectives |
|---|---|
| Topic 1: Pituitary and Hypothalamic Disorders | - Diabetes insipidus and SIADH - Pituitary adenomas and hypopituitarism |
| Topic 2: Calcium, Bone and Metabolic Disease | - Osteoporosis and metabolic bone disease - Calcium and vitamin D disorders |
| Topic 3: Diabetes Mellitus | - Diabetic complications and emergencies - Type 1 and Type 2 diabetes management |
| Topic 4: Reproductive Endocrinology | - Polycystic ovary syndrome (PCOS) - Hypogonadism and infertility |
| Topic 5: Thyroid Disease | - Hyperthyroidism and hypothyroidism - Thyroid nodules and cancer |
| Topic 6: Metabolic Disorders | - Obesity management - Lipid disorders |
| Topic 7: Neuroendocrine Tumours and Multiple Endocrine Neoplasia | - Carcinoid and pancreatic NETs - MEN syndromes |
| Topic 8: Endocrine Emergencies | - Thyroid and adrenal crisis - Diabetic ketoacidosis and hyperosmolar states |
| Topic 9: Adrenal Disorders | - Cushing syndrome - Addison disease and adrenal insufficiency |
Question 1
A 30-year-old man was reviewed in the diabetes clinic. He had type 1 diabetes mellitus of 6 months' duration, treated with subcutaneous insulin in a basal bolus regimen (short-acting insulin three times daily; long-acting insulin once daily).
Investigations:
haemoglobin A1c52 mmol/mol (20-42)
At what arterialised venous blood glucose threshold would a patient typically expect to develop neuroglycopenic symptoms?
A. 3.5-3.9 mmol/L
B. 2.7-3.0 mmol/L
C. <2.3 mmol/L
D. 3.1-3.4 mmol/L
E. 2.3-2.6 mmol/L
Question 2
A 57-year-old man was admitted to hospital with joint pains. He was found to have gout. He had been found to have type 2 diabetes mellitus at the age of 47 years and developed nephropathy 7 years later. He was taking metformin 1 g twice daily, ramipril 5 mg twice daily and gliclazide 80 mg twice daily. The admitting team advised him to take ibuprofen 400 mg three times daily as needed.
On examination, his pulse was 87 beats per minute and his blood pressure was 146/85 mmHg. He had an inflamed right hallux.
Investigations:
serum sodium131 mmol/L (137-144)
serum potassium5.1 mmol/L (3.5-4.9)
serum creatinine156 umol/L (60-110)
estimated glomerular filtration rate (MDRD)42 mL/min/1.73 m2 (>60)
haemoglobin A1c72 mmol/mol (20-42)
random plasma glucose23.0 mmol/L
What is the most appropriate step in management?
A. stop ibuprofen alone
B. stop gliclazide and withhold metformin
C. stop ibuprofen and withhold metformin
D. stop gliclazide and ibuprofen
E. withhold metformin alone
Question 3
A 58-year-old woman was referred with an incidental finding of mild hypercalcaemia. She had no relevant symptoms or significant medical history. She was taking no medication.
Investigations:
serum creatinine101 umol/L (60-110) serum corrected calcium2.71 mmol/L (2.20-2.60) serum alkaline phosphatase78 U/L (45-105)
plasma parathyroid hormone6.8 pmol/L (0.9-5.4) serum 25-OH-cholecalciferol76 nmol/L (45-90)
What is the most appropriate next investigation?
A. parathyroid isotope scan
B. calcium:creatinine clearance ratio
C. calcium-sensing receptor gene mutation analysis
D. bone mineral density scan
E. ultrasound scan of neck
Question 4
A 48-year-old man presented with gynaecomastia. His serum oestradiol was increased and a CT scan of adrenal glands revealed a 13-cm tumour of the left adrenal gland. Further workup showed increased secretion of 17-hydroxyprogesterone, cortisol and androstenedione. A diagnosis of adrenocortical carcinoma was suspected.
Investigations:
staging CT scan of chest and abdomenno evidence of metastasis
What is the most appropriate next step in management?
A. left adrenalectomy followed by adjuvant combination chemotherapy
B. adrenal fine-needle biopsy
C. left adrenalectomy followed by adjuvant mitotane treatment
D. iodocholesterol scan
E. MR scan of adrenal glands with chemical shift analysis
Question 5
A 20-year-old woman with Turner's syndrome had heard that there was a risk of ovarian cancer associated with Turner's syndrome. She asked to undergo a pre-emptive oophorectomy.
For what genotype is oophorectomy most likely to be recommended?
A. 45X/46Xxi (Xq)
B. 45X/46XX
C. 45X/46XY
D. 45XO
E. 45X/47XXX
Solutions:
| Question 1 Answer: B | Question 2 Answer: C | Question 3 Answer: B | Question 4 Answer: C | Question 5 Answer: C |
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